HISTORY OF IDIOPATHIC-HYPERSOMNIA (IH)

Idiopathic hypersomnia (IH) is a rare neurological sleep disorder characterized by excessive daytime sleepiness, long or unrefreshing naps, and difficulty waking up, even after extended periods of sleep. While it shares some features with narcolepsy, idiopathic hypersomnia is a distinct condition with its own clinical profile and challenges. The journey to understanding IH has been slow, marked by decades of misdiagnosis, limited research, and evolving diagnostic criteria. This timeline highlights key milestones in the recognition, classification, and treatment of idiopathic hypersomnia. It offers a clearer picture of how far the field has come and how much more work remains.

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Summary Table of Challenges

Challenge Description
Lack of Biomarkers

No objective neurobiological markers for IH

Test Limitations

MSLT/PSG have low sensitivity and reliability for IH

Symptom Overlap

Difficult to distinguish from NT2 and other hypersomnias

Exclusion of Other Conditions

Requires ruling out many other causes of sleepiness

Diagnostic criteria limitations

ICSD-3 lacks nuance; long sleep time not easily measured

Medication/Comorbidity Confounding

Medications and comorbidities can alter test results

Underrecognition/Delays

IH is rare and often misdiagnosed, leading to long delays in care

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