Clinical Trials

Clinical Trials: Advancing Narcolepsy & IH Research

Explore active studies that aim to improve care, discover new treatments, and elevate the voices of those living with Narcolepsy and IH. Your experience matters.

What Are

Clinical trials are research studies that involve human participants and are designed to evaluate medical, surgical, or behavioral interventions. They are essential to advancing our understanding of how new treatments work — whether that’s a medication, a device (like a pacemaker), a therapy, or even a lifestyle change.

For people with narcolepsy or idiopathic hypersomnia, clinical trials help determine whether new options are safe, effective, and potentially more beneficial than current treatments. They also offer participants a chance to contribute to future breakthroughs that could improve the lives of others with the same condition.

Why Participate?

Clinical trials aren’t just about science — they’re about people. Participating gives you the opportunity to:

Access potential new treatments before they’re widely available

Contribute to critical research that may improve future care

Help researchers understand real-world impacts of sleep disorders

Current and Upcoming Clinical Trials Seeking Participants

Here are some of the clinical studies currently enrolling individuals with narcolepsy or idiopathic hypersomnia. Each study has different requirements and goals — be sure to review eligibility before applying.

REVITALYZ Study (Avadel)

A Phase 3 clinical trial evaluating the safety and effectiveness of a study drug for idiopathic hypersomnia in adults.

Vibrance Studies (Alkermes plc)

Now enrolling participants for studies related to excessive daytime sleepiness (EDS).

FirstLight Study (Takeda Pharmaceuticals)

Research focused on individuals with Narcolepsy Type 1 (with cataplexy) to explore new treatment possibilities.

ORX750 Study – CRYSTAL-1 (Centessa Pharmaceuticals)

Investigating ORX750 in people with narcolepsy or idiopathic hypersomnia.

Beth Israel Deaconess Medical Center

Survey-based study exploring the relationship between Narcolepsy Type 1 and recent pregnancy outcomes.

Mayo Clinic

Seeking participants ages 18–65 with idiopathic hypersomnia to study the effects of low-sodium oxybate.

CATNAP® Pediatric Narcolepsy Registry

A web-based registry collecting data from children under 18 with narcolepsy and their caregivers to better understand the impact on health and quality of life.
📄 [Click here for more info.]

DUET Study (Jazz Pharmaceuticals)

Exploring how XYWAV® (low-sodium oxybate) affects daytime and nighttime symptoms in people with IH or narcolepsy (Types 1 or 2).

📄 [Click here for the brochure.]

Emory Sleepiness Research

Enrolling participants for a study on the antibiotic clarithromycin for treatment of narcolepsy (Types 1 & 2) and IH.

Boston Children’s Hospital

Focused on improving social and relationship health in adolescents with narcolepsy or IH.

Zevra Therapeutics – Study KP1077.D01

Evaluating KP1077 capsules for safety and efficacy in adults with idiopathic hypersomnia.
📍 [Find a study location here.]

IQVIA

Looking for adults (18+) diagnosed with narcolepsy or IH, currently taking Xywav®, to participate in a paid research study.

Know a Study We Should Share?

If you’re aware of a clinical trial, registry, or research initiative not listed here that may help others in the community, we’d love to hear from you. Please send us the link and a brief description so we can consider adding it.